Comparison of flunixin pharmacokinetics and milk elimination in healthy cows and cows with mastitis

Authors

  • L. W. Kissell Department of Population Health and Pathobiology and the Food Animal Residue Avoidance and Depletion Program, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607
  • T. L. Leavens Department of Population Health and Pathobiology and the Food Animal Residue Avoidance and Depletion Program, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607
  • R. E. Baynes Department of Population Health and Pathobiology and the Food Animal Residue Avoidance and Depletion Program, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607
  • J. E. Riviere Department of Population Health and Pathobiology and the Food Animal Residue Avoidance and Depletion Program, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607
  • G. W. Smith Department of Population Health and Pathobiology and the Food Animal Residue Avoidance and Depletion Program, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607

DOI:

https://doi.org/10.21423/aabppro20134237

Keywords:

Flunixin meglumine, NSAID, dairy cattle, endotoxemia, bovine respiratory disease, acute bovine mastitis, 5-hydroxy flunixin, pharmacokinetics, milk elimination

Abstract

Flunixin meglumine (FLU) is a non-steroidal anti-inflammatory drug that is labeled for use in dairy cattle for regulation of inflammation in endotoxemia and for the control of pyrexia associated with bovine respiratory disease and acute bovine mastitis at a dose of 1.0 mg/lb (2.2 mg/kg), IV every 24 hours or 0.5 mg/lb (1.1 mg/kg), IV, every 12 hours. The milk withdrawal time for FLU is 36 hours. Currently, FLU is the second most common violative drug residue found in the dairy industry. The reason for the numerous illegal FLU drug residues remains unclear; however, prolonged clearance in cows with mastitis, compared with that in healthy cows is one possible explanation. Cows with mastitis may have prolonged elimination of 5-hydroxy flunixin (5OH), the marker residue for FLU in milk, which results in milk FLU residues greater than the tolerance limit of 2 ppb after 36 hours. The objective of this study was to determine if the pharmacokinetics and milk elimination of FLU and 5OH differed between healthy cows and cows with mastitis.

Cover image of the 46th Conference Proceedings: An image of cattle standing in a field during th day. They are looking rather indignantly at the camera. Yellow background.

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Published

2013-09-19

Issue

2013

Section

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