Elimination Kinetics of Tilmicosin Following Intramammary Administration in Lactating Dairy Cattle

Authors

  • G. W. Smith Dept. of Population Health and Pathobiology, North Carolina State University, Raleigh, NC 27606
  • J. L. Davis Dept. of Clinical Sciences, North Carolina State University, Raleigh, NC 27606
  • R. E. Baynes Dept. of Population Health and Pathobiology, North Carolina State University, Raleigh, NC 27606
  • J. E. Riviere Dept. of Population Health and Pathobiology, North Carolina State University, Raleigh, NC 27606

DOI:

https://doi.org/10.21423/aabppro20084428

Keywords:

macrolide antibiotic, respiratory disease, intramammary, mastitis, extralabel drug use, tilmicosin

Abstract

Tilmicosin is a macrolide antibiotic approved for both the treatment and control of respiratory disease in beef cattle and dairy cattle under 20 months of age. The drug is not approved for use in lactating dairy cattle; however, tilmicosin is sometimes used in an extralabel manner by bovine practitioners for the intramammary treatment of mastitis. This practice results in detectible residues and has resulted in several instances of milk residue violation referred to the Food Animal Residue Avoidance Databank (FARAD). The purpose of this study was to determine the elimination kinetics of tilmicosin in milk following an intramammary infusion so an appropriate proper milk withdrawal interval could be determined.

Cover image of the 41st Conference Proceedings: A herd of cattle standing in the field, framed by a cloudy sky. Yellow background.

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Published

2008-09-25

Issue

2008

Section

Research Summaries

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