Ceftiofur Crystalline Free Acid Sterile Suspension (CCFA-SS) in Cattle

Pharmacokinetics after Injection in the Middle Third of the Ear and Importance of Injection Technique

Authors

  • Scott A. Brown Pharmacia Animal Health, Kalamazoo, Michigan, USA 49001
  • Fred Lehman Pharmacia Animal Health, Kalamazoo, Michigan, USA 49001
  • Merlyn J. Lucas Pharmacia Animal Health, Kalamazoo, Michigan, USA 49001
  • Joseph A. Robinson Pharmacia Animal Health, Kalamazoo, Michigan, USA 49001
  • Edward J. Robb Pharmacia Animal Health, Kalamazoo, Michigan, USA 49001

DOI:

https://doi.org/10.21423/aabppro20035292

Keywords:

Ceftiofur, antibiotic, bovine respiratory disease, CCFA-SS, administration, plasma ceftiofur concentration

Abstract

Ceftiofur, a time-dependent, bactericidal antibiotic active against bovine respiratory disease pathogens, is effective when the concentrations remain above the minimum inhibitory concentration (MIC) for at least 3-5 days. A new product, CCFA-SS, is a prolonged release formulation of ceftiofur, intended to provide single dose efficacy in cattle. It is administered subcutaneously (SC) in the ear, eliminating any injection in edible tissue. The objective of this study was to generate plasma ceftiofur concentration data following administration of CCFA-SS SC in the middle third of the posterior aspect of the ear.

Cover image of the 36th Conference Proceedings: Holstein cows standing in a row at a fence. One cow has put her head through the fence and is curiously inspecting a pile of hay. Yellow background.

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Published

2003-09-18

Issue

2003

Section

Research Summaries - Beef