Comparison of neutralizing antibodies to type 1a, 1b and 2 bovine viral diarrhea virus from experimentally infected and vaccinated cattle

Authors

  • Lisa Jones Department of Veterinary Sciences, University of Wyoming, 1174 Snowy Range Rd., Laramie, WY 82070
  • Hana Van Campen Department of Veterinary Sciences, University of Wyoming, 1174 Snowy Range Rd., Laramie, WY 82070
  • Zhi-Chang Xu Fort Dodge Animal Health, P. 0. Box 518, Fort Dodge, IA 50501
  • John A. Schnackel Fort Dodge Animal Health, P. 0. Box 518, Fort Dodge, IA 50501

DOI:

https://doi.org/10.21423/bovine-vol35no2p137-140

Keywords:

beef cattle, experimental infection, heifers, humoral immunity, mucosal disease, neutralizing antibodies, vaccination

Abstract

Serum neutralizing (SN) antibody titres to cytopathic (cp) type 1a, type 1b and type 2 bovine viral diarrhoea viruses (BVDV) were determined for yearling, crossbred beef heifers immunized with a modified live cytopathic type 1a BVDV vaccine, or experimentally infected with a noncytopathic (ncp) type 1b or a ncp type 2 BVDV. The results indicate that type-specific and cross-reactive SN titres are usually found to all three test viruses in an individual animal, with the highest SN titres to the same genotype of BVDV as the challenge or vaccine virus. Exceptions to this trend were found in individual animals, however, emphasizing the importance of comparing the SN titres for several animals in a herd. Determining SN titres to the three BVDV genotypes may help veterinarians distinguish the BVDV genotype involved in a herd infection from antibody titres due to vaccination.

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Published

2001-06-01

How to Cite

Jones, L., Van Campen, H., Xu, Z.-C., & Schnackel, J. A. (2001). Comparison of neutralizing antibodies to type 1a, 1b and 2 bovine viral diarrhea virus from experimentally infected and vaccinated cattle. The Bovine Practitioner, 35(2), 137–140. https://doi.org/10.21423/bovine-vol35no2p137-140

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Section

Articles