Efficacy and long-lasting activity of spiramycin in young beef cattle with infectious enzootic broncho-pneumonia
DOI:
https://doi.org/10.21423/bovine-vol0no24p38-41Keywords:
Antibiotics, Bacterial diseases, bronchitis, cattle diseases, Pneumonia, Respiratory diseases, spiramycin, aminoglycoside antibiotics, macrolide antibioticsAbstract
Multicentric clinical trials performed in young beef cattle with I.E.B.P. demonstrated the excellent efficacy of spiramycin at an optimum dose of 100?000 IU/kg. The recommended frequency of administration in curative treatment is 2 injections at a 48 hour interval and the clinical recovery rate is 80-90%. A single injection of 100?000 IU/kg confers very high protection in metaphylactic treatment. The activity of spiramycin against Mycoplasma and Pasteurella, the principal agents involved in I.E.B.P., may be explained by the excellent diffusion and concentration of this antibiotic in the lung tissue and bronchial secretions.