The Effect of Anti-Prostaglandin Therapy in an Acute Respiratory Distress Syndrome Induced in Experimental Cattle by the Oral Administration of 3, Methylindole

Abstract

Paper presented at the Xlllth World Congress on Cattle Diseases, Durban, S. Africa, Sept. 17-21, 1984.   Ten yearling Friesian steers were given 0.1 g/kg 3MI by stomach tube. The respiratory distress syndrome that subsequently arose was alleviated by the administration of flunixin meglumine. After seven days there were still distinct clinical differences between test and control cattle. The initial therapeutic response was probably due to a reduction in the severity of pulmonary congestion and oedema; the latter benefits were probably due to the differences between test and control steers in the extent and severity of alveolar epithelial hyperplasia.