Inhibition of Bovine Herpesvirus 1 and Bovine Viral Diarrhea Virus Replication by Genistein

a Compound in Soybeans

Authors

  • D. Peterson Department of Veterinary Science South Dakota State University, Brookings, SD 57007
  • A. Shaw Department of Veterinary Science South Dakota State University, Brookings, SD 57007
  • A. A. El-Sheikh Department of Veterinary Science South Dakota State University, Brookings, SD 57007
  • L. J. Braun Department of Veterinary Science South Dakota State University, Brookings, SD 57007
  • C. Y. Wang Department of Nutrition and Food Science, South Dakota State University, Brookings, SD 57007
  • C. C. L. Chase Department of Veterinary Science South Dakota State University, Brookings, SD 57007

DOI:

https://doi.org/10.21423/aabppro20015220

Keywords:

herpesvirus, bovine viral diarrhea virus, cattle pathogen, Genistein, in vitro replication, soybeans, anti-viral drug

Abstract

Bovine herpesvirus type 1 (BHV-1, IBR), an alphaherpesvirus, and bovine viral diarrhea virus (BVDV), a pestivirus, are important cattle pathogens. Genistein, a naturally occurring flavonoid in soybeans, inhibits in vitro replication of herpes simplex virus 1, another alphaherpesvirus. Genistein has also been used to protect against a wide range of animal and human conditions including cancer, cardiovascular disease, loss of brain function, osteoporosis and menopausal symptoms. This makes genistein an excellent candidate for use as an anti-viral drug. Genistein was tested for its ability to inhibit the replication of BHV-1 and BVDV.

Cover image of the 34th Conference Proceedings: Four men on horseback lead a single cow through a pen. Yellow background.

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Published

2001-09-13

Issue

2001

Section

Research Summaries - General

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